PGT- M : Ensure your baby’s good health and minimize the risk of genetic disorder
Preimplantation Genetic Testing for Monogenic disorders (PGT-M) is a specialized genetic testing procedure used to detect specific genetic disorders caused by mutations in a single gene. PGT-M is used to identify embryos that carry a specific genetic disorder before they are implanted into the uterus, increasing the chances of having a healthy child.
During PGT-M, a small number of cells are removed from an embryo created through in-vitro fertilization (IVF) and analyzed for specific genetic mutations associated with a particular disorder. This can be done by using techniques such as PCR, Sanger sequencing, or Next generation sequencing (NGS).
PGT-M can be used to test for a wide range of monogenic disorders, such as cystic fibrosis, sickle cell anemia, Tay-Sachs disease, and many others. It’s important to note that PGT-M is not a diagnostic test and is not always able to detect all genetic mutations. Therefore it is important to seek genetic counseling before making any decision about undergoing PGT-M.
– PGT-M is Recommended for:
- Couples who have a family history of a specific genetic disorder: PGT-M can be used to identify embryos that do not carry the genetic mutation associated with the disorder and increase the chances of having a healthy child.
- Couples who are carriers of a specific genetic disorder: PGT-M can be used to identify embryos that carry the genetic mutation associated with the disorder and allow couples to make informed decisions about family planning.
- Couples who have previously had a child with a specific genetic disorder: PGT-M can be used to identify embryos that do not carry the genetic mutation associated with the disorder and increase the chances of having a healthy child in the future.
- Couples with recurrent miscarriage: PGT-M can be used to identify embryos that carry genetic mutations associated with recurrent miscarriage, and increase the chances of a successful pregnancy.
- Couples with advanced reproductive age: As women age, the risk of having a child with genetic disorders increases. PGT-M can be used to identify embryos that do not carry genetic mutations associated with these disorders, and increase the chances of a successful pregnancy.
– How is the PGT-M performed?
Preimplantation genetic diagnosis begins with the normal process of in vitro fertilization that includes egg retrieval and fertilization in a laboratory. Over the next three days the embryo will divide into eight cells.
Preimplantation genetic diagnosis involves the following steps:
- First, one or two cells are removed from the embryo.
- The cells are then evaluated to determine if the inheritance of a problematic gene is present in the embryo.
- Once the PGT-M procedure has been performed and embryos free of genetic problems have been identified, the embryo will be placed back in the uterus, and implantation will be attempted.
- Any additional embryos that are free of genetic problems may be frozen for later use while embryos with the problematic gene are destroyed.