IVF proves to be a great option for couples who cannot conceive naturally. However, there is a small portion of couples who face difficulties in conceiving through a 3rd day embryo transfer through IVF. Some of these couples do not see results until they go through multiple cycles of IVF, while some do not see results at all. For these couples, a great alternative is to opt for a blastocyst transfer on day 5 instead of fertilization instead.
What is a blastocyst? A blastocyst is an advanced stage of an embryo that usually happens on the 4th or 5th day of fertilization. This is then transferred to the uterus of the expecting female. To understand it better, it is important to understand the basic differences between a 3rd, 4th, and 5th-day transfer of an embryo.
An embryo starts off as a single cell that divides every 12-24 hours. By the third day of fertilisation, the embryo has divided into 4 or 8 cells and is called a multicellular embryo. This is the stage where most natural IVF Cycles are performed. A 3rd Day embryo transfer is the most commonly used practice in IVF and usually has a high success rate if all the conditions are in the favour of the patient.
4th Day Transfer
Around the time of the 4 day, the embryo has divided into 16 cells and has arrived at the stage of what is medically known as Morula. Transfering the morula as part of an IVF Cycle is an unconventional method, though not totally unheard of. There is little scientific evidence that suggests that 4th day Morula transfers are in any way more or less successful than embryo transfer on the 3rd day.
5th Day Transfer
A blastocyst is an advanced stage of the embryo where the cell has differentiated into 2 different cell types, with more than 70-100 cells between them. The first one is the inner cell mass which will then turn into the tissues of the baby as it develops, while the other is the trophoblast or trophoectoderm, which forms part of the placenta. This cell division is the major reason why blastocyst transfer on the 5th-6th day are more successful than embryo transfer on the 3rd day. This is especially true and helpful for couples who have been through IVF cycles to no avail or have other reasons behind their inability to conceive naturally.
Q. What is the success rate of blastocyst transfers?
Because of the difference of environment in the fallopian tube and the uterus, the blastocyst are more equipped to survive than the embryos. As a result, blastocyst transfer are as much as 80% successful in helping infertile couples.
Q. What happens after a blastocyst transfer?
After transfer, the blastocyst hatches out of its shell and attaches itself to the uterus by the end of day 2. Then the blastocyst begins to attach itself deeper into the uterine lining, beginning the implantation which continues till day 5th. The fetal and placenta tissue begin to develop, releasing the Human chorionic gonadotropin (hCG) into the blood stream. After the 9th Day, the hCG levels in the blood get to a level enough to detect confirmed pregnancy.
Q. How long does it take for a blastocyst to implant?
About 5 days after the transfer, the blastocyst completely implants itself to the uteral lining.
Q. Does sleeping position affect implantation?
There is no evidence that suggests that a certain sleeping position is better for implantation than others. The blastocyst is transferred on the right time and when the womb is ready for it. What matters is that the expecting mother should be comfortable.
Q. What are the chances of a 5 day blastocyst implantation?
A 5th day blastocyst transfer is more successful than a 3rd day embryo transfer. For more information, get in touch with our experts by booking an appointment now.
Q. What should you not do during implantation?
The Don’ts of blastocyst transfer include:
- No alcohol
- No smoking
- No caffeine
- No fizzy drinks
- Avoid heavy lifting and strenuous activities
- Avoid hot baths